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But most women who undergo IUI also take a fertility drug. Fertility drugs and other treatments primarily increase your chance of having fraternal twins, where two eggs are. I had 2 large follies 20 and 22 and just had an IUI today. I'm wondering if that means I'm at greater risk for twins? Or is 2 follies a low number? My The Nichols Family: Stephanie and David with IUI twins Caleb and Alexis, and IVF twins Brayden and Sierra. The journey through infertility treatment can be long and disappointing. California Couple Has Two Sets of Twins with IUI and IVF at West Coast Fertility . The Nichols Family: Stephanie and David, with IUI twins Caleb and Alexis, and IVF twins Brayden and. Me-35, DH-42, TTC #1 - 25 mnths, 3 IUI (2 Clomid, 1 Reprnx) - BFN IVF #1 - m/c twins 7.5 wks (9/04) - Elev. Homocysteine/Hetero MTHFR IVF #2 - BFN (12/04) What are your views on selective reduction? Think about what you are comfortable with. The incidence of eggs splitting causing monozygotic (identical) twins during IVF is. of high order multiples, he says he'd prefer we go straight to IVF than start with IUI.. My chance of multiples is about 20%, but the nurse explained that most of those are twins. IUI can use sperm from the male partner or a donor. It is often combined with. For more information, see the topic Multiple Pregnancy: Twins or More.